How Obesity Abets Type 2 Diabetes
Human fat can be healthy or sick - healthy in lean people and sick in obese. And a new research effort shows sick fat cells can produce proteins that contribute to type 2 diabetes.
The study, performed by researchers at Temple University, discovered that fat cells in obese people bear a great deal of stress in a cellular component called the endoplasmic reticulum, which is the cells' protein factory. The stress, says lead researcher Dr. Guenther Boden, apparently produces proteins connected with insulin resistance, a major contributor to obesity-related diabetes. In particular, 19 proteins were more abundant in obese people's fat cells than lean people's, including three that were related to a specific endoplasmic reticulum stress-related response. (Read more about How Obesity Abets Type 2 Diabetes)
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